Dr. Feng Xie, MD, Professor of Medicine
Feng Xie, MD
Professor of Medicine
Division of Cardiovascular Medicine
University of Nebraska Medical Center
982265 Nebraska Medical Center
Omaha, NE 68198-2265, USA
Dr. Feng Xie graduated from the Jiamusi Medical School in 1975. His cardiology training took place at
the Chinese PLA Postgraduate Medical School during 1982-1985. He went to the University of
Rochester Medical Center for an advanced postdoctoral training from 1986 – 1987. He became an
associate professor and vice director in the Department of Diagnostic Ultrasound at the Chinese PLA
General Hospital in 1990. In 1992, he spent one year at the University of Pennsylvania Medical Center as
a visiting professor. He worked at the University of Nebraska Medical Center as a research associate and
instructor from 1993-1995. In 1996, he was appointed as a Chief of Department of Ultrasound at Chinese
Cardiovascular Institute and Fuwai Heart Hospital, Peking Union Medical College and Chinese Medical
Academy. In 1999, he returned to the University of Nebraska Medical Center. He is currently a professor of
medicine in Division of Cardiovascular Medicine.
He is a member of the American Heart Association and American Society of Echocardiography. He was Vice
President and Cardiovascular Imaging Chair of CNAHA. He served for American Journal of Cardiology,
Journal of American Society of Echocardiography and American Heart Journal as a reviewer. During his
early year in China, Dr. Xie was very active in leadership roles in numerous academic societies for many
years. He had been nominated and elected to several prominent leadership positions on Committees,
Boards and Medical Societies. He was the Vice Chairman of the Beijing Society of Ultrasound in
Medicine, Council of Chinese Association of Ultrasound in Medicine and Engineering; Board for Foreign
The affair of the Chinese Association of Ultrasound in Medicine and Engineering; Board of Chinese Medical
Association; and Board of Beijing Society for Echocardiography. Dr. Xie has been recognized both
nationally and internationally for his achievements in the field of echocardiography. He received a
number of nationally and internationally recognized prizes and awards, including Research Award
Winner at Fifth Annual Scientific Session of American (1994), and The Heritage Prize for Excellence in
Creative Activity, Li Foundation, New York, NY (1995). Dr. Xie’s research interests are cardiac imaging
and therapeutic ultrasound with microbubbles in coronary heart diseases. He is working several projects
as the principal investigator and co-investigator funded by NIH. He has published more than 300+
articles in Circulation, Journal of American College of Cardiology, European Heart Journal etc. Dr. Xie’s
most influential contributions in echocardiography were two original articles published in Circulation and
JACC. The gas theory and experimental evidence proposed in the article directly lead to the advent of
new ultrasound contrast agents. The TRI phenomenon observed in the paper also laid the foundation for
the development of low mechanical index instruments and its patents were also adopted by
manufacturers. These two papers are considered as classics of contrast echo and have been widely cited.
谢峰， 教授，主任医师，博士生导师。1985年毕业于解放军军医学院（解放军总医院
）研究生院，获硕士学位。1986 -1987年在罗切斯特大学心内科进行博士后研究。1990年成
为解放军总医院超声诊断科副主任、副教授。1992-1993年为美国宾夕法尼亚大学访问教授
。1993－1995任职于美国内布拉斯加大学。1996年回国被任命为北京协和医科大学、中国医
学科学院阜外心血管病医院超声科主任、教授，博士生导师。1999年谢峰教授再次回到内布
拉斯加大学医学中心心血管医学科，历任助教授、副教授、教授。
谢峰是美国心脏学会会员、美国超声心动图学会会员、美国华裔心脏协会副主席、医
学影像部主任。谢峰早年在中国期间，担任众多社会职务，包括中华医学会北京超声学会副
主任委员、中国心血管技术培训中心副主任委员、中国医学科学院高级职称评委等。若干国
内和美国专业杂志的编委审稿人。谢峰在其职业生涯中获得一系列奖项，包括1994年ASE
Research Award第一名、1995年度美国李氏基金奖、并多次获得中国超声医学杂志一等奖。
谢峰的研究兴趣是心脏影像学和超声与微泡的诊断和治疗学领域。他目前作为PI或共同研究
者，正在进行几个NIH项目的研究。他已在同行评审的杂志上发表了300余篇学术论文，这些
杂志包括：Circulation, Journal of American College of Cardiology, European Heart Journal
等。谢峰的原始性工作得到了广泛的引用，其h-index约为38。谢峰教授在国际心血管领域最
有影响力的贡献是1995年与Porter教授共同发表在Circulation和JACC的两篇原始论著。文章
提出的气体理论和实验证据直接导致了新型声学造影剂的问世。文中观察到的TRI现象也为日
后低机械指数仪器的发展奠定了基础，其专利也被厂家采用。这两篇论文堪称心脏声学造影
的经典文献，被国内外学者大量引用。
Publications (recent 5 years, total 300+)
1. Jinjin Liu; Shunji Gao; Thomas Porter; Carr Everbach; William Shi; Francois Vignon;
Jeffry Powers; John Lof; Joseph Turner; Feng Xie. Transcranial threshold of inertial
cavitation induced by diagnostic ultrasound and microbubbles. AIP Conference
Proceedings. 1481: 221-226. 2012
2. Francois Vignon; W.T. Shi; J.E. Powers; J. Liu; L. Drvol; J. Lof; C. Everbach; S. Gao; F.
Xie; T. Porter. Real-time two-dimensional imaging of microbubble cavitation. AIP
Conference Proceedings. 1481: 407-413. 2012
3. Liu Z, Gao S, Zhao Y, Li P, Liu J, Li P, Tan K, Xie F. Disruption of tumor
neovasculature by microbubble enhanced ultrasound: A potential new physical therapy of
anti-angiogenesis. Ultrasound in Medicine and Biology. 38: 253-261. 2012
4. Porter TR, Xie F. Can transcranial ultrasound and microbubble therapy ever enter the
mainstream in acute stroke therapy? Expert Review of Cardiovascular Therapy. 10: 549-
551. 2012
5. Kutty S, Olson J, Danford CJ, Sandene EK, Xie F, Fletcher SE, Erickson CC, Kugler JD,
Danford DA, Porter TR. Ultrasound contrast and real-time perfusion in conjunction with
supine bicycle stress echocardiography for comprehensive evaluation of surgically
corrected congenital heart disease. European Heart Journal Cardiovascular Imaging. 13:
500-509. 2012
6. Thomas D, Xie F, Smith LM, O'Leary E, Smith K, Olson J, Nalty K, Hess R, Graham M,
Therrien S, Porter TR. Prospective randomized comparison of conventional stress
echocardiography and real-time perfusion stress echocardiography in detecting significant
coronary artery disease. J Am Soc Echocardiogr. 25: 1207-1214. 2012
7. Kutty S, Wu J, Hammel JM, Xie F, Gao S, Drvol LK, Lof J, Radio SJ, Therrien SL,
Danford DA, Porter TR. Microbubble Mediated Thrombus Dissolution with Diagnostic
Ultrasound for the Treatment of Chronic Venous Thrombi. PLoS ONE. 7: e51453. 2012
8. Xie F, Gao S, Wu J, Lof J, Radio S, Vignon F, Shi W, Powers J, Unger E, Everbach EC,
Liu J, Porter TR. Diagnostic Ultrasound Induced Inertial Cavitation to Non-Invasively
Restore Coronary and Microvascular Flow in Acute Myocardial Infarction. PLoS ONE.
8: e69780. 2013
9. Vignon F, Shi WT, Powers JE, Everbach EC, Liu J, Gao S, Xie F, Porter TR.
Microbubble cavitation imaging. IEEE Transactions on Ultrasonics, Ferroelectrics, and
Frequency Control. 60: 661-670. 2013
10. Gao S, Zhu Q, Dong X, Chen Z, Liu Z, Xie F. Guided longer pulses from a diagnostic
ultrasound and intraclot microbubble enhanced catheter-directed thrombolysis in vivo.
Ultrasound in Medicine and Biology. 44: 48-56. 2017
11. Porter TR, Smith LM, Wu J, Thomas D, Haas JT, Mathers DH, Williams E, Olson J,
Nalty K, Hess R, Therrien S, Xie F. Patient outcome following 2 different stress imaging
approaches: A prospective randomized comparison. J Am Coll Cardiol. 61: 2446-2455.
2013
12. Shunji Gao; Zheng Liu; Feng Xie. Reply to the letter to the editor re "Disruption of
tumor neovasculature by microbubble enhanced ultrasound: A potential new physical
therapy of anti-angiogenesis". Ultrasound in Medicine and Biology. 40: 456. 2014
13. Juefei Wu; Feng Xie; Tanmay Kumar; Jinjin Liu; John Lof; William Shi; E. Carr
Everbach; Thomas R. Porter. Improved Sonothrombolysis from a Modified Diagnostic
Transducer Delivering Impulses Containing a Longer Pulse Duration. Ultrasound in
Medicine and Biology. 2014
14. Juefei Wu; Feng Xie; Tanmay Kumar; Jinjin Liu; John Lof; William Shi; E. Carr
Everbach; Thomas R. Porter. Improved sonothrombolysis from a modified diagnostic
transducer delivering impulses containing a longer pulse duration. Ultrasound in
Medicine and Biology. 40: 1545-1553. 2014
15. Gao S, Zhang Y, Wu J, Shi WT, Lof J, Vignon F, Drvol L, Xie F, Muirhead D, Powers
JE, High R, White ML, Porter TR. Improvements in cerebral blood flow and
recanalization rates with transcranial diagnostic ultrasound and intravenous microbubbles
after acute cerebral emboli. Invest Radiol. 49: 593-600. 2014
16. Thomas R. Porter; Feng Xie. Contrast Echocardiography: Latest Developments and
Clinical Utility. Current Cardiology Reports. 17: 2015
17. Zenab Laiq; Lynette M. Smith; Feng Xie; Mohammed Chamsi-Pasha; Thomas R. Porter.
Differences in patient outcomes after conventional versus real time perfusion stress
echocardiography in men versus women: A prospective randomised trial. Heart. 101:
559-564. 2015
18. Juefei Wu; Feng Xie; John Lof; Samer Sayyed; Thomas R. Porter. Utilization of
modified diagnostic ultrasound and microbubbles to reduce myocardial infarct size.
Heart. 101: 1468-1474. 2015
19. Sahar S. Abdelmoneim; Sharon L. Mulvagh; Feng Xie; Edward O'Leary; Mary
Adolphson; Mohamed A. Omer; Lara F. Nhola; Runqing Huang; Sara J. Warta; Brenda
Kirby; Thomas R. Porter. Regadenoson Stress Real-Time Myocardial Perfusion
Echocardiography for Detection of Coronary Artery Disease: Feasibility and Accuracy of
Two Different Ultrasound Contrast Agents. J Am Soc Echocardiogr. 28: 1393-1400. 2015
20. Wenhong Gao; Lu Qiao; Yuejuan Gao; Li Zhang; Dong Zhang; Juan Tu; Zheng Liu;
Feng Xie. Effect of microbubble-enhanced ultrasound on percutaneous ethanol ablation
of rat walker-256 tumour. European Radiology. 1-9. 2015
21. Porter TR, Arena C, Sayyed S, Lof J, High RR, Xie F, Dayton PA. Targeted
Transthoracic Acoustic Activation of Systemically Administered Nanodroplets to Detect
Myocardial Perfusion Abnormalities. Circulation: Cardiovascular Imaging, 2016;
Jan;9(1). pii: e003770. doi: 10.1161
22. Roos ST, Juffermans L, van Royen N, van Rossum AC, Xie F, Appelman Y, Porter TR,
Kamp O. Unexpected high incidence of coronary vasoconstriction in the Reduction of
microvascular injury using s onolysis (ROMUS) trial. Ultrasound Med Biol
2016;42:1919-28
23. Mathias W Jr., Tsutsui JM, Tavares BG, Xie F, Aquiar MO, Garcia DR, Oliveria MT,
Soeiro A, Nicolau JC, Lemos PA Neto, Rochittte CE, Ramires JA, Kalil R Filho, Porter
TR. Diagnostic ultrasound impulses improve microvascular flow in patients with STEMI
receiving intravenous microbubbles. J Am Coll Cardiol 2016; 67:2506-2515
24. Porter TR, Choudhury S, Xie F. Utilization of Diagnostic Ultrasound and Intravenous
Lipid Encapsulated Perfluorocardons in Non-Invasive Targeted Cardiovascular
Therapeutics. Journal of Therapeutic Ultrasound. 2016;4:18 doi: 10.1186/s40349-016-
0062-y. eCollection 2016
25. Gaibazzi N, Lorenzoni V, Reverberi C, Wu J, Xie F, Porter TR. Effect of pharmacologic
stress test result on outcome of obese versus non-obese subjects referred for stress
perfusion echocardiography. J Am Soc Echocardiogr. 2016; S0894-7317(16)30225-5
26. Kutty S, Xiao Y, Olson J, Xie F, Danford DA, Erickson CC, Porter TR. Safety and
efficacy of cardiac ultrasound contrast in children and adolescents for resting and stress
echocardiography J Am Soc Echocardiogr. 2016;29;655-62
27. Wu J, Barton D, Xie F, O’Leary E, Steuter J, Pavlides G, Porter TR. Comparison of
fractional flow reserve assessment with demand stress myocardial contrast
echocardiography in angiographically intermediate coronary stenosis. Cir Cardiovasc
Imaging 2016;9:e004129
28. Porter TR, Xie F, Therapeutic uses of contrast microbubbles. Current Cardiovascular
Imaging Reports, 2016;9:24
29. Porter TR, Radio S, Lof J, Everbach C, Powers J, Vignon F, Shi WT, Xie F. Diagnostic
ultrasound high mechanical index impulses restore microvascular flow In peripheral
arterial thromboembolism. Ultrasound Med Biol 2016;42:1531-40
30. Choudhury SA, Xie F, Dayton PA, Porter TR. Acoustic behavior of a reactivated,
commercially available ultrasound contrast agent. J Am Soc Echocardiogr. 2017;30:189-
197.
31. Chamsi-Pasha MA, Xie F, Smith LS, Mile C, Porter TR. Prognostic value of demand
stress real time perfusion imaging in patients with advanced kidney disease undergoing
renal transplantation. J Am Coll Cardiol: Cardiovascular Imaging. 2017;10:1528-1529
32. Baibhav B, Mahabir CA, Xie F, Shostrom VK, McCashland T, Porter TR. Predictive
value of dobutamine stress perfusion echocardiography in contemporary end stage liver
disease. J Am Heart Assoc. 2017;6:e005102
33. Porter TR, Xie F, Lof J, Powers J, Vignon F, Shi W, White M. The thrombolytic effect of
diagnosis ultrasound induced microbubble cavitation in acute carotid thromboembolism.
Investigative Radiology: 2017;52:477-481
34. Kutty S, Liu N, Zhou J, Xiao Y, Wu J, Danford F, Lof J, Xie F, Porter TR. Ultrasound
induced microbubble cavitation for the treatment of catheterization induced vasospasm.
JACC: Basic to Translational Scienc. 2017: Dec;2:748-756
35. Aggarwal S, Xie F, Porter TR. Masking and UnMasking of Isolated Noncompaction of
the Left Ventricle with Real-Time Contrast Echocardiography. Circulation:
Cardiovascular Imaging. 2017;10:e006999
36. Gao S, Zhu Q, Guo M, Gao Y, Dong X, Chen Z, Liu Z, Xie F. Ultrasound and Intra-Clot
Microbubbles Enhanced Catheter-Directed Thrombolysis in Vitro and in Vivo.
Ultrasound in Medicine and Biology. 2017;43 : 1671-1678
37. Gao S, Zhu Q, Dong X, Chen Z, Liu Z, Xie F . Guided longer pulses from a diagnostic
ultrasound and intraclot microbubble enhanced catheter-directed thrombolysis in vivo. J
Thromb Thrombolysis. 2017;44:48-56.
38. Zhu Q, Gao S, Guo M, Gao Y, Liu Z, Xie F. Intraclot microbubble combined with
urokinase mediated ultrasound thrombolysis: Experiment in vitro. Chinese Journal of
Interventional Imaging and Therapy, 2017;14:242-246
